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A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria.
There are some others as well that play a less significant role.Non-sedating antihistamines are as effective as others but offer additional benefits.Although antihistamines are by no means a recent discovery, the development of the new class of non-sedating antihistamines allows many more allergy sufferers to benefit from the therapeutic effects of the drugs without experiencing their annoying and often unmanageable side effects such as sedation, which is a condition or state in which one feels overly calm and serene; it is akin to being tranquillized.For years, the cost of relief for these people was feeling groggy and out of sorts for hours.Histamine is responsible for the immune response to the stimuli that we are familiar in symptoms as itching, sneezing, hives, runny nose and watery eyes. Traditional antihistamines act by minimizing swelling and controlling the dilation of small blood vessels that translate to those common allergy symptoms.
They accomplished this by blocking the histamine from connecting with its receptors in specific nerve, muscle and glandular types of cells.These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism.Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.Loratadine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle.Loratadine does not cross the blood-brain barrier and does not cause central nervous system effects.Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.